Click the tabs below to learn more about the individual cores.
- D. Wade Clapp, MD, Co-Core Director (Indiana University School of Medicine)
- Kevin Shannon, MD, Co-Core Director (University of California, San Francisco)
- Lang Li, PhD, Co-Investigator and Bioinformatics Data Integration Leader (Indiana University School of Medicine)
The Administrative Core coordinates research within the SPORE and oversight by the program’s advisory boards. SPORE components include the four translational research projects summarized above as well as a Developmental Research Program (DRP), a Career Development Program (CDP), and specialized core resources (Biospecimen/Pathology Core and Omics Core). Members of the External and Internal Advisory Boards are listed in the Figure.
- Gary L Johnson, PhD, Core Director (University of North Carolina)
- David Eberhard, MD, PhD, Co-Investigator (University of North Carolina)
- Shawn Gomez, Co-Investigator (University of North Carolina)
- Piotr Mieczkowski, PhD, Co-Investigator (University of North Carolina)
- Joel Parker, PhD, Co-Investigator (University of North Carolina)
The Omics Core will advance the scientific goals of Projects 1-4 by providing proteomic and genomic platforms for performing RNAseq and whole exome sequencing analysis combined with comprehensive kinome activation measurements. This core will be led and coordinated by Dr. Gary Johnson (UNC). Dr. Johnson is Director of the Human Genome RNAi Screening Facility that provides automated genome-wide RNAi screens. This core has extensive next-generation sequencing and informatics experience with the TCGA and will provide a comprehensive infrastructure for the four SPORE projects by providing state-of-the-art services for exome and transcriptome (RNA) sequencing. The Omics Core will also provide additional innovative chemical proteomic methods that allow assay en masse of the activation state of 75-80% of the expressed kinome in tumor cells. The Administrative Core, coordinated by the IU biostatistician and bioinformaticist Dr. Li, will have primary responsibility for performing biostatistical and bioinformatic analyses.
- Tatiana M. Foroud, PhD, Co-Core Director, Biospecimen (Indiana University School of Medicine)
- Andrew E. Horvai, MD, PhD, Co-Core Director, Pathology (University of California, San Francisco)
- Scott Kogan, MD, Co-Core Director, Pathology (University of California, San Francisco)
The Biospecimen/Pathology Core brings together a team with expertise in pathology and sample banking. This core will be co-led by Drs. Tatiana Foroud (IU), Andrew Horvai (UCSF), and Scott Kogan (UCSF).
A key function of the Biospecimen/Pathology Core will be to serve as the central site to track and store samples and pathological data from the human and mouse biospecimens collected as part of the four SPORE projects. This core will perform pathological review of all samples and will make these data available to SPORE investigators and the broader research community. The biospecimens will be banked in this core and then distributed to the Omics Core for deep molecular analysis. In addition, the Biospecimen/Pathology Core will maintain an electronic catalog which will link the specimens and tissue to the pathological reports as well as data generated in the projects for each study subject. The project investigators will use this electronic catalog to select the samples needed for analyses.